The human UDP-glycosyltransferase (UGTs) superfamily has 22 functional enzymes that play a critical role in the metabolism of small lipophilic compounds, including carcinogens, drugs, steroids, lipids, fatty acids, and bile acids. We further identified the UGT genes whose intratumoral expression was associated with patient survival, highlighting the potential of UGT genes as prognostic biomarkers and therapeutic targets in various cancers. Briefly, our comprehensive analysis of the transcriptomic (RNAseq) and clinical datasets of 9514 patients from 33 different cancers shows the widespread expression of UGT genes, indicative of active drug metabolism within the tumor through the UGT conjugation pathway. The present study represents the first to comprehensively assess the expression profiles of UGT genes and their impact on patient survival in nearly 30 different cancers primarily derived from non-drug-metabolizing organs. Previous studies have documented the expression of UGT genes in several cancers derived from drug-metabolizing organs (e.g., liver, colon, kidney).
The human UDP-glycosyltransferase (UGT) superfamily plays a critical role in the metabolism of numerous endogenous and exogenous small lipophilic compounds, including carcinogens, drugs, and bioactive molecules with pro- or anti-cancer activity.
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